Abstract
Acetone-butanol-ethanol (ABE) fermentation is a metabolic process of clostridia that produces bio-based solvents including butanol. It is enabled by an underlying metabolic reaction network and modulated by cellular gene regulation and environmental cues. Mathematical modeling has served as a valuable strategy to facilitate the understanding, characterization and optimization of this process. In this review, we highlight recent advances in system-level, quantitative modeling of ABE fermentation. We begin with an overview of integrative processes underlying the fermentation. Next we survey modeling efforts including early simple models, models with a systematic metabolic description, and those incorporating metabolism through simple gene regulation. Particular focus is given to a recent system-level model that integrates the metabolic reactions, gene regulation and environmental cues. We conclude by discussing the remaining challenges and future directions towards predictive understanding of ABE fermentation.
Original language | English (US) |
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Article number | fnw074 |
Journal | FEMS microbiology letters |
Volume | 363 |
Issue number | 9 |
DOIs | |
State | Published - Apr 3 2016 |
Keywords
- ABE fermentation
- Butanol
- Mathematical modeling
- System-level integration
- Systems biology
ASJC Scopus subject areas
- General Medicine