Several variations have been explored of the general synthesis of chlorins which uses a photochemical ring-closure of the macrocycle as the key step. This work leads to a synthesis of (±)-Faktor-I octamethyl ester, a chlorin which arises, in the free-acid form, by aromatisation of the mono-C-methylated intermediate on the biosynthetic pathway to vitamin B12. This synthesis confirms the structure of Faktor-I and allows labelled samples to be prepared.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|State||Published - 1988|
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