TY - JOUR
T1 - Synthetic Models for Nickel-Iron Hydrogenase Featuring Redox-Active Ligands
AU - Schilter, David
AU - Gray, Danielle L.
AU - Fuller, Amy L.
AU - Rauchfuss, Thomas B.
N1 - The authors thank Dr James Camara for the preparation of mppf and Dr Mark Nilges for assistance with EPR spectroscopy. This work was supported by the National Institutes of Health (GM46441).
PY - 2017
Y1 - 2017
N2 - The nickel-iron hydrogenase enzymes efficiently and reversibly interconvert protons, electrons, and dihydrogen. These redox proteins feature iron-sulfur clusters that relay electrons to and from their active sites. Reported here are synthetic models for nickel-iron hydrogenase featuring redox-active auxiliaries that mimic the iron-sulfur cofactors. The complexes prepared are NiII(-H)FeIIFeII species of formula [(diphosphine)Ni(dithiolate)(-H)Fe(CO)2(ferrocenylphosphine)]+ or NiIIFeIFeII complexes [(diphosphine)Ni(dithiolate)Fe(CO)2(ferrocenylphosphine)]+ (diphosphine=Ph2P(CH2)2PPh2 or Cy2P(CH2)2PCy2; dithiolate=-S(CH2)3S-; ferrocenylphosphine=diphenylphosphinoferrocene, diphenylphosphinomethyl(nonamethylferrocene) or 1,1′-bis(diphenylphosphino)ferrocene). The hydride species is a catalyst for hydrogen evolution, while the latter hydride-free complexes can exist in four redox states-a feature made possible by the incorporation of the ferrocenyl groups. Mixed-valent complexes of 1,1′-bis(diphenylphosphino)ferrocene have one of the phosphine groups unbound, with these species representing advanced structural models with both a redox-active moiety (the ferrocene group) and a potential proton relay (the free phosphine) proximal to a nickel-iron dithiolate.
AB - The nickel-iron hydrogenase enzymes efficiently and reversibly interconvert protons, electrons, and dihydrogen. These redox proteins feature iron-sulfur clusters that relay electrons to and from their active sites. Reported here are synthetic models for nickel-iron hydrogenase featuring redox-active auxiliaries that mimic the iron-sulfur cofactors. The complexes prepared are NiII(-H)FeIIFeII species of formula [(diphosphine)Ni(dithiolate)(-H)Fe(CO)2(ferrocenylphosphine)]+ or NiIIFeIFeII complexes [(diphosphine)Ni(dithiolate)Fe(CO)2(ferrocenylphosphine)]+ (diphosphine=Ph2P(CH2)2PPh2 or Cy2P(CH2)2PCy2; dithiolate=-S(CH2)3S-; ferrocenylphosphine=diphenylphosphinoferrocene, diphenylphosphinomethyl(nonamethylferrocene) or 1,1′-bis(diphenylphosphino)ferrocene). The hydride species is a catalyst for hydrogen evolution, while the latter hydride-free complexes can exist in four redox states-a feature made possible by the incorporation of the ferrocenyl groups. Mixed-valent complexes of 1,1′-bis(diphenylphosphino)ferrocene have one of the phosphine groups unbound, with these species representing advanced structural models with both a redox-active moiety (the ferrocene group) and a potential proton relay (the free phosphine) proximal to a nickel-iron dithiolate.
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U2 - 10.1071/CH16614
DO - 10.1071/CH16614
M3 - Article
AN - SCOPUS:85018263263
SN - 0004-9425
VL - 70
SP - 505
EP - 515
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
IS - 5
ER -