Synthetic Biomaterials to Rival Nature's Complexity—a Path Forward with Combinatorics, High-Throughput Discovery, and High-Content Analysis

Douglas Zhang, Junmin Lee, Kristopher A. Kilian

Research output: Contribution to journalArticlepeer-review

Abstract

Cells in tissue receive a host of soluble and insoluble signals in a context-dependent fashion, where integration of these cues through a complex network of signal transduction cascades will define a particular outcome. Biomaterials scientists and engineers are tasked with designing materials that can at least partially recreate this complex signaling milieu towards new materials for biomedical applications. In this progress report, recent advances in high throughput techniques and high content imaging approaches that are facilitating the discovery of efficacious biomaterials are described. From microarrays of synthetic polymers, peptides and full-length proteins, to designer cell culture systems that present multiple biophysical and biochemical cues in tandem, it is discussed how the integration of combinatorics with high content imaging and analysis is essential to extracting biologically meaningful information from large scale cellular screens to inform the design of next generation biomaterials.

Original languageEnglish (US)
Article number1700535
JournalAdvanced Healthcare Materials
Volume6
Issue number19
DOIs
StatePublished - Oct 11 2017

Keywords

  • biomaterials
  • tissue engineering
  • tumor microenvironment

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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