Synthetic biology moving into the clinic

Warren C. Ruder, Ting Lu, James J. Collins

Research output: Contribution to journalReview articlepeer-review


Synthetic biology is an emerging field focused on engineering biomolecular systems and cellular capabilities for a variety of applications. Substantial progress began a little over a decade ago with the creation of synthetic gene networks inspired by electrical engineering. Since then, the field has designed and built increasingly complex circuits and constructs and begun to use these systems in a variety of settings, including the clinic. These efforts include the development of synthetic biology therapies for the treatment of infectious diseases and cancer, as well as approaches in vaccine development, microbiome engineering, cell therapy, and regenerative medicine. Here, we highlight advances in the biomedical application of synthetic biology and discuss the field's clinical potential.

Original languageEnglish (US)
Pages (from-to)1248-1252
Number of pages5
Issue number6047
StatePublished - Sep 2 2011
Externally publishedYes

ASJC Scopus subject areas

  • General


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