Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles

Scott J. Barraza, Scott E. Denmark

Research output: Contribution to journalArticle

Abstract

Silicon-containing compounds have been largely ignored in drug design and development, despite their potential to improve not only the potency but also the physicochemical and ADMET (absorption, distribution, metabolism, excretion, toxicity) properties of drug-like candidates because of the unique characteristics of silicon. This deficiency is in large part attributable to a lack of general methods for synthesizing diverse organosilicon structures. Accordingly, a new building block strategy has been developed that diverges from traditional approaches to incorporation of silicon into drug candidates. Flexible, multi-gram-scale syntheses of silicon-containing tetrahydroquinoline and tetrahydroisoquinoline building blocks are described, along with methods by which diversely functionalized silicon-containing nitrogen heterocycles can be rapidly built using common reactions optimized to accommodate the properties of silicon. Furthermore, to better clarify the liabilities and advantages of silicon incorporation, select compounds and their carbon analogues were challenged in ADMET-focused biological studies.

Original languageEnglish (US)
Pages (from-to)6668-6684
Number of pages17
JournalJournal of the American Chemical Society
Volume140
Issue number21
DOIs
StatePublished - May 30 2018

Fingerprint

Silicon
Metabolism
excretion
silicon
Toxicity
Nitrogen
metabolism
toxicity
nitrogen
drug
Silicon Compounds
Tetrahydroisoquinolines
Pharmaceutical Preparations
Drug Design
Drug-Related Side Effects and Adverse Reactions
liability
distribution
Carbon
carbon

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles. / Barraza, Scott J.; Denmark, Scott E.

In: Journal of the American Chemical Society, Vol. 140, No. 21, 30.05.2018, p. 6668-6684.

Research output: Contribution to journalArticle

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