Synthesis of unsymmetrical biaryls from arylsilacyclobutanes

Scott E Denmark; Zhicai Wu

doi:10.1021/ol991054k

Synthesis of unsymmetrical biaryls from arylsilacyclobutanes

Scott E Denmark, Zhicai Wu

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(formula presented) Aryl(fluoro)silacyclobutanes and aryl(chloro)silacyclobutanes have been found to undergo cross-coupling reactions with aryl iodides. The rate of reaction and extent of homocoupling were dramatically affected by the addition of ligands for the palladium catalyst. With (t-Bu) ₃ P a wide range of electronically and structurally diverse unsymmetrical biaryls have been prepared in good to excellent yields.

Original language	English (US)
Pages (from-to)	1495-1498
Number of pages	4
Journal	Organic Letters
Volume	1
Issue number	9
DOIs	https://doi.org/10.1021/ol991054k
State	Published - Nov 4 1999

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Synthesis of unsymmetrical biaryls from arylsilacyclobutanes",

abstract = " (formula presented) Aryl(fluoro)silacyclobutanes and aryl(chloro)silacyclobutanes have been found to undergo cross-coupling reactions with aryl iodides. The rate of reaction and extent of homocoupling were dramatically affected by the addition of ligands for the palladium catalyst. With (t-Bu) 3 P a wide range of electronically and structurally diverse unsymmetrical biaryls have been prepared in good to excellent yields. ",

author = "Denmark, {Scott E} and Zhicai Wu",

year = "1999",

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doi = "10.1021/ol991054k",

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AU - Wu, Zhicai

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N2 - (formula presented) Aryl(fluoro)silacyclobutanes and aryl(chloro)silacyclobutanes have been found to undergo cross-coupling reactions with aryl iodides. The rate of reaction and extent of homocoupling were dramatically affected by the addition of ligands for the palladium catalyst. With (t-Bu) 3 P a wide range of electronically and structurally diverse unsymmetrical biaryls have been prepared in good to excellent yields.

AB - (formula presented) Aryl(fluoro)silacyclobutanes and aryl(chloro)silacyclobutanes have been found to undergo cross-coupling reactions with aryl iodides. The rate of reaction and extent of homocoupling were dramatically affected by the addition of ligands for the palladium catalyst. With (t-Bu) 3 P a wide range of electronically and structurally diverse unsymmetrical biaryls have been prepared in good to excellent yields.

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