Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging

Amanda K. East; Michael C. Lee; Lukas P. Smaga; Chang Jiang; Sharath C. Mallojjala; Jennifer S. Hirschi; Jefferson Chan

doi:10.1021/acs.orglett.2c03382

Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging

Amanda K. East, Michael C. Lee, Lukas P. Smaga, Chang Jiang, Sharath C. Mallojjala, Jennifer S. Hirschi, Jefferson Chan

Research output: Contribution to journal › Article › peer-review

Abstract

SWIR dyes offer many advantages over their more common NIR congeners; however, the available options are limited. New SWIR imaging agents can be accessed by remodeling existing NIR molecules (i.e., hemicyanines (HDs)). In this study, we synthesized SWIR-HD, a modified HD featuring dimethylsilicon and benzo[cd]indolium groups that are designed to red-shift the absorbance and emission to 988 and 1126 nm, respectively. SWIR-HD was employed to visualize the liver and tumors via multimodal SWIR imaging.

Original language	English (US)
Pages (from-to)	8509-8513
Number of pages	5
Journal	Organic Letters
Volume	24
Issue number	46
DOIs	https://doi.org/10.1021/acs.orglett.2c03382
State	Published - Nov 25 2022

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.2c03382

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title = "Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging",

abstract = "SWIR dyes offer many advantages over their more common NIR congeners; however, the available options are limited. New SWIR imaging agents can be accessed by remodeling existing NIR molecules (i.e., hemicyanines (HDs)). In this study, we synthesized SWIR-HD, a modified HD featuring dimethylsilicon and benzo[cd]indolium groups that are designed to red-shift the absorbance and emission to 988 and 1126 nm, respectively. SWIR-HD was employed to visualize the liver and tumors via multimodal SWIR imaging.",

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doi = "10.1021/acs.orglett.2c03382",

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T1 - Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging

AU - East, Amanda K.

AU - Lee, Michael C.

AU - Smaga, Lukas P.

AU - Jiang, Chang

AU - Mallojjala, Sharath C.

AU - Hirschi, Jennifer S.

AU - Chan, Jefferson

PY - 2022/11/25

Y1 - 2022/11/25

N2 - SWIR dyes offer many advantages over their more common NIR congeners; however, the available options are limited. New SWIR imaging agents can be accessed by remodeling existing NIR molecules (i.e., hemicyanines (HDs)). In this study, we synthesized SWIR-HD, a modified HD featuring dimethylsilicon and benzo[cd]indolium groups that are designed to red-shift the absorbance and emission to 988 and 1126 nm, respectively. SWIR-HD was employed to visualize the liver and tumors via multimodal SWIR imaging.

AB - SWIR dyes offer many advantages over their more common NIR congeners; however, the available options are limited. New SWIR imaging agents can be accessed by remodeling existing NIR molecules (i.e., hemicyanines (HDs)). In this study, we synthesized SWIR-HD, a modified HD featuring dimethylsilicon and benzo[cd]indolium groups that are designed to red-shift the absorbance and emission to 988 and 1126 nm, respectively. SWIR-HD was employed to visualize the liver and tumors via multimodal SWIR imaging.

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JO - Organic Letters

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Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging

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