Synthesis of Proline-Valine Pseudodipeptide Enol Lactones, Serine Protease Inhibitors

Research output: Contribution to journalArticlepeer-review

Abstract

The fragmentation of 9-bromobornan-2-ol derivatives is dependent on both the orientation and identity of the leaving group at the 2-position. This has led to a synthesis of compounds containing useful quaternary carbon centers in carbocyclic six-membered rings, a previously unknown type of chiral pool elements.

Original languageEnglish (US)
Pages (from-to)2624-2634
Number of pages11
JournalJournal of Organic Chemistry
Volume56
Issue number8
DOIs
StatePublished - Apr 1 1991

ASJC Scopus subject areas

  • Organic Chemistry

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