Synthesis of polypeptides by ring-opening polymerization of α-Amino acid N-carboxyanhydrides

Jianjun Cheng, Timothy J. Deming

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter summarizes methods for the synthesis of polypeptides by ring-opening polymerization. Traditional and recently improved methods used to polymerize α-amino acid N-carboxyanhydrides (NCAs) for the synthesis of homopolypeptides are described. Use of these methods and strategies for the preparation of block copolypeptides and side-chain-functionalized polypeptides are also presented, as well as an analysis of the synthetic scope of different approaches. Finally, issues relating to obtaining highly functional polypeptides in pure form are detailed.

Original languageEnglish (US)
Title of host publicationPeptide-Based Materials
EditorsTimothy Deming
Number of pages26
StatePublished - 2012
Externally publishedYes

Publication series

NameTopics in Current Chemistry
ISSN (Print)0340-1022


  • Amino acid
  • Block copolymer
  • N-Carboxyanhydride
  • Polymerization
  • Polypeptide

ASJC Scopus subject areas

  • General Chemistry


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