@article{7fb6994208d5428598bbc64ac936b530,
title = "Synthesis of (+)-Pancratistatins via Catalytic Desymmetrization of Benzene",
abstract = "A concise synthesis of (+)-pancratistatin and (+)-7-deoxypancratistatin from benzene using an enantioselective, dearomative carboamination strategy has been achieved. This approach, in combination with the judicious choice of subsequent olefin-type difunctionalization reactions, permits rapid and controlled access to a hexasubstituted core. Finally, minimal use of intermediary steps as well as direct, late stage C-7 hydroxylation provides both natural products in six and seven operations.",
author = "Hernandez, {Lucas W.} and Jola Pospech and Ulrich Kl{\"o}ckner and Bingham, {Tanner W.} and David Sarlah",
note = "Funding Information: Financial support for this work was provided by the University of Illinois, the National Science Foundation (CAREER Award No. CHE-1654110), and the NIH/National Institute of General Medical Sciences (GM122891). D.S. is an Alfred P. Sloan Fellow. L.H. acknowledges the National Institute of General Medical Sciences (NIGMS)-NIH Chemistry-Biology Interface Training Grant and J.P. and U.K. thanks the German Research Foundation (DFG) for postdoctoral fellowships. We thank Profs. S. E. Denmark and P. J. Hergenrother (University of Illinois) for critical proofreading of this paper and W. R. Grace and Co. for a gift of Raney-cobalt. We also thank Dr. D. Olson and Dr. L. Zhu for NMR spectroscopic assistance, Dr. D. L. Gray for X-ray crystallographic analysis assistance, and F. Sun for mass spectrometric assistance. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = nov,
day = "8",
doi = "10.1021/jacs.7b10351",
language = "English (US)",
volume = "139",
pages = "15656--15659",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "44",
}