Synthesis of heterocycles containing two cytosine or two guanine base- pairing sites. Novel tectons for self-assembly

Paul M. Petersen, Weiming Wu, Edward E. Fenlon, Sungho Kim, Steven C. Zimmerman

Research output: Contribution to journalArticle

Abstract

The synthesis of 1 and 2 is described, as is the X-ray structure of 1. Tecton 1 contains two DAA hydrogen bonding sites (cytosine-like), while 2 contains two DDA sites (guanosine-like). Tectons 1 and 2 were designed to self-assemble into a helical superstructure. Self-recognition of 1 occurs in the solid state with a novel inclusion of dimethylacetamide solvent.

Original languageEnglish (US)
Pages (from-to)1107-1112
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume4
Issue number7
DOIs
StatePublished - Jul 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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