Synthesis of Halo Enol Lactones. Mechanism-Based Inactivators of Serine Proteases

Keyphrases

• Halo 100%
• Serine Protease 100%
• Enol Lactones 100%
• Mechanism-based Inactivator 100%
• γ-butyrolactone 71%
• Cyclization 42%
• Bromo 28%
• Active Sites 28%
• Methylene 28%
• Inactivator 28%
• Methyl 14%
• γ-Valerolactone 14%
• Trimethylsilyl 14%
• Bromine 14%
• Benzoic Acid 14%
• Trans-addition 14%
• α-keto Acids 14%
• Chymotrypsin 14%
• Efficient Synthesis 14%
• Suicide 14%
• Halogenation 14%
• Iodine 14%
• Chloro 14%
• Aqueous Two-phase System 14%
• Hydrolytic Stability 14%
• Halogens 14%
• 3(2H)-furanones 14%
• Acyl Transfer 14%
• 2(5H)-furanone 14%
• Phase-transfer Catalysis 14%
• Enones 14%
• Olefin Isomerization 14%
• Enzymatic Study 14%
• Enolization 14%
• Halolactonization 14%
• Vinylics 14%
• α-haloketones 14%
• Mercuric Ion 14%
• Nucleophilic Site 14%
• Baeyer-Villiger Oxidation 14%
• Serine Hydrolase 14%

Chemistry

• Serine 100%
• Lactone 100%
• Enol 100%
• Hexynoic Acid 50%
• Isomerization 16%
• Alkene 16%
• Benzoic Acid 16%
• Keto Acids 16%
• Ketone 16%
• Enone 16%
• Phase Transfer Catalysis 16%
• Halolactonization 16%
• Baeyer-Villiger Oxidation 16%