Synthesis of Cyclophanes Derived from l-Amino-3,7-dialkyl-4-methylnaphthalenes

D. S. Kemp, M. E. Garst, R. W. Harper, D. D. Cox, D. Carlson, S. Denmark

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Abstract

A practical five-step route is described to 1,6-bis(l,-amino-3'-carbethoxy-4'-methyl-7'-naphthyl)hexane (6) in 23% yield from 1,6-diphenylhexane. From 6 are prepared two 3,7-bridged naphthalene-derived cyclophanes, 1,8-[3,7][l-(dimethylamino)-4-methylnaphtha]-3,6-dithiacyclotetradecaphane (15) and 1,11-[3,7][l-(dimethylamino)-4-methylnaphtha]-2,10-diketo-3,9-di-iV-methylazacycloheptadecaphane1 (13).

Original languageEnglish (US)
Pages (from-to)4469-4473
Number of pages5
JournalJournal of Organic Chemistry
Volume44
Issue number25
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

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