Synthesis of controlled, high-molecular weight poly(l-glutamic acid) brush polymers

Ryan Baumgartner, Diane Kuai, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review


We report the synthesis and characterization of high-molecular weight poly(l-glutamic acid) based brush polymers. Utilizing a combination of ring-opening metathesis polymerization of norbornene based monomers and ring-opening polymerization of γ-benzyl-l-glutamate N-carboxyanhydride, high-molecular weight γ-benzyl protected poly(l-glutamic acid) brush polymers are synthesized. Controlled and complete deprotection of the benzyl groups using trimethylsilyl iodide resulted in poly(l-glutamic acid) based brush polymers with molecular weights up to 3.6 MDa, which may potentially be used to prepare size-controlled unimolecular polymeric nanomedicine for drug delivery applications. Camptothecin brush poly(l-glutamic acid) conjugates were prepared and their stability, drug release kinetics, and in vitro toxicity were studied.

Original languageEnglish (US)
Pages (from-to)1836-1844
Number of pages9
JournalBiomaterials Science
Issue number9
StatePublished - Sep 2017

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)


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