Synthesis of biphenyl proteomimetics as estrogen receptor-a coactivator binding inhibitors

Anna B. Williams; Patrick T. Weiser; Robert N. Hanson; Julian R. Günther; John A. Katzenellenbogen

doi:10.1021/ol901999f

Synthesis of biphenyl proteomimetics as estrogen receptor-a coactivator binding inhibitors

Anna B. Williams, Patrick T. Weiser, Robert N. Hanson, Julian R. Günther, John A. Katzenellenbogen

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

"Chemical Equation Presented" A novel series of blphenyl proteomlmetic compounds were designed as estrogen receptor-α (ERα) coactivator binding Inhibitors. Synthesis was accomplished through a convergent approach, employing Suzuki coupling chemistry to ligate the Individual modular units. Initial biological results support the ability of these compounds to compete for the ERα coactivator binding groove.

Original language	English (US)
Pages (from-to)	5370-5373
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	23
DOIs	https://doi.org/10.1021/ol901999f
State	Published - Dec 3 2009

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol901999f

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AU - Katzenellenbogen, John A.

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Synthesis of biphenyl proteomimetics as estrogen receptor-a coactivator binding inhibitors

Abstract

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