Synthesis of an ethylene glycol cross-linked amino acid

Mengfei Ho; Weiheng Wang; Maria Douvlos; Thuha Pham; Klock Timothy

doi:10.1016/S0040-4039(00)79646-8

Synthesis of an ethylene glycol cross-linked amino acid

Mengfei Ho, Weiheng Wang, Maria Douvlos, Thuha Pham, Klock Timothy

Research output: Contribution to journal › Article › peer-review

Abstract

Synthesis of an ethylene glycol-containing amino acid, (2R,9S)-N²-Cbz-N⁹-Boc,2,9-diamino-4,7-dioxadecanedioic acid 1-phenacyl 10-methyl diester 1, was studied through direct alkylation of N-Boc-L-serine and through BF₃-catalyzed ring opening of N-acylaziridinecarboxylates.

Original language	English (US)
Pages (from-to)	1283-1286
Number of pages	4
Journal	Tetrahedron Letters
Volume	32
Issue number	10
DOIs	https://doi.org/10.1016/S0040-4039(00)79646-8
State	Published - Mar 4 1991
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "Synthesis of an ethylene glycol-containing amino acid, (2R,9S)-N2-Cbz-N9-Boc,2,9-diamino-4,7-dioxadecanedioic acid 1-phenacyl 10-methyl diester 1, was studied through direct alkylation of N-Boc-L-serine and through BF3-catalyzed ring opening of N-acylaziridinecarboxylates.",

author = "Mengfei Ho and Weiheng Wang and Maria Douvlos and Thuha Pham and Klock Timothy",

year = "1991",

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doi = "10.1016/S0040-4039(00)79646-8",

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T1 - Synthesis of an ethylene glycol cross-linked amino acid

AU - Ho, Mengfei

AU - Wang, Weiheng

AU - Douvlos, Maria

AU - Pham, Thuha

AU - Timothy, Klock

PY - 1991/3/4

Y1 - 1991/3/4

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AB - Synthesis of an ethylene glycol-containing amino acid, (2R,9S)-N2-Cbz-N9-Boc,2,9-diamino-4,7-dioxadecanedioic acid 1-phenacyl 10-methyl diester 1, was studied through direct alkylation of N-Boc-L-serine and through BF3-catalyzed ring opening of N-acylaziridinecarboxylates.

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Synthesis of an ethylene glycol cross-linked amino acid

Abstract

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