Synthesis of a selenocysteine-containing peptide by native chemical ligation

Matt D. Gieselman, Lili Xie, Wilfred A. Van Der Donk

Research output: Contribution to journalArticlepeer-review


(equation presented) A new method for the synthesis of selenocysteine derivatives and selenocysteine-containing peptides is described. Fmoc-Se-p-methoxybenzylselenocysteine (1) was prepared and used for solid-phase synthesis of peptides with an N-terminal unprotected selenocysteine. Subsequent native chemical ligation with a peptide thioester provided a 17-mer that corresponds to the C-terminus of ribonucleotide reductase with selenocysteine in place of cysteine.

Original languageEnglish (US)
Pages (from-to)1331-1334
Number of pages4
JournalOrganic Letters
Issue number9
StatePublished - May 3 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Synthesis of a selenocysteine-containing peptide by native chemical ligation'. Together they form a unique fingerprint.

Cite this