Synthesis of 2-amino-3-fluoroacrylic acid containing peptides

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(Matrix presented) Peptides containing (E)- and (Z)-3-fluorodehydroalanine have been prepared from serine via a fluoro-Pummerer rearrangement. The resulting electrophilic moieties may be useful affinity labels for the identification of the targets of dehydroamino acid containing natural products that act by covalent mechanisms.

Original languageEnglish (US)
Pages (from-to)593-596
Number of pages4
JournalOrganic Letters
Issue number4
StatePublished - Feb 22 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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