TY - JOUR
T1 - Synthesis and evaluation of hexahydrochrysene and tetrahydrobenzofluorene ligands for the estrogen receptor
AU - Tedesco, Rosanna
AU - Youngman, Michael K.
AU - Wilson, Scott R.
AU - Katzenellenbogen, John A.
N1 - Funding Information:
This work was supported through research grants from the NIH (5R37 DK15556 and CA18119) and instrumentation grants from the NIH and NSF. We are grateful to Kathryn Carlson, Jun Sun and Benita Katzenellenbogen for biological assays.
PY - 2001/5/21
Y1 - 2001/5/21
N2 - To prepare novel estrogen receptor (ER) ligands, we have developed a facile approach to substituted hexahydrochrysene and tetrahydrobenzo[a]fluorene systems. Substituents, including basic side chains, were added to these systems, and their binding affinity to ERα and ERβ, and in some cases their transcriptional activity were evaluated.
AB - To prepare novel estrogen receptor (ER) ligands, we have developed a facile approach to substituted hexahydrochrysene and tetrahydrobenzo[a]fluorene systems. Substituents, including basic side chains, were added to these systems, and their binding affinity to ERα and ERβ, and in some cases their transcriptional activity were evaluated.
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U2 - 10.1016/S0960-894X(01)00189-5
DO - 10.1016/S0960-894X(01)00189-5
M3 - Article
C2 - 11392537
AN - SCOPUS:0035927191
SN - 0960-894X
VL - 11
SP - 1281
EP - 1284
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 10
ER -