Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

Eli Moore, Andrew T. Zill, Cyrus A. Anderson, Aljosha R. Jochem, Steven C. Zimmerman, Claudine S. Bonder, Tobias Kraus, Helmut Thissen, Nicolas H. Voelcker

Research output: Contribution to journalArticle

Abstract

This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights. (Figure presented.).

Original languageEnglish (US)
Pages (from-to)2252-2261
Number of pages10
JournalMacromolecular Chemistry and Physics
Volume217
Issue number20
DOIs
StatePublished - Oct 1 2016

Keywords

  • bioconjugation
  • click reaction
  • hyperbranched polymers

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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  • Cite this

    Moore, E., Zill, A. T., Anderson, C. A., Jochem, A. R., Zimmerman, S. C., Bonder, C. S., Kraus, T., Thissen, H., & Voelcker, N. H. (2016). Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols. Macromolecular Chemistry and Physics, 217(20), 2252-2261. https://doi.org/10.1002/macp.201500507