Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

Eli Moore; Andrew T. Zill; Cyrus A. Anderson; Aljosha R. Jochem; Steven C. Zimmerman; Claudine S. Bonder; Tobias Kraus; Helmut Thissen; Nicolas H. Voelcker

doi:10.1002/macp.201500507

Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

Eli Moore, Andrew T. Zill, Cyrus A. Anderson, Aljosha R. Jochem, Steven C. Zimmerman, Claudine S. Bonder, Tobias Kraus, Helmut Thissen, Nicolas H. Voelcker

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights. (Figure presented.).

Original language	English (US)
Pages (from-to)	2252-2261
Number of pages	10
Journal	Macromolecular Chemistry and Physics
Volume	217
Issue number	20
DOIs	https://doi.org/10.1002/macp.201500507
State	Published - Oct 1 2016

Keywords

bioconjugation
click reaction
hyperbranched polymers

ASJC Scopus subject areas

Condensed Matter Physics
Materials Chemistry
Polymers and Plastics
Physical and Theoretical Chemistry
Organic Chemistry

Online availability

10.1002/macp.201500507

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title = "Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols",

abstract = "This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights. (Figure presented.).",

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AU - Anderson, Cyrus A.

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AU - Zimmerman, Steven C.

AU - Bonder, Claudine S.

AU - Kraus, Tobias

AU - Thissen, Helmut

AU - Voelcker, Nicolas H.

PY - 2016/10/1

Y1 - 2016/10/1

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AB - This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights. (Figure presented.).

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Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

Abstract

Keywords

ASJC Scopus subject areas

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