Syntheses relevant to vitamin B12 biosynthesis: Synthesis of sirohydrochlorin and of its octamethyl ester

Michael H. Block, Steven C. Zimmerman, Graeme B. Henderson, Simon P.D. Turner, Steven W. Westwood, Finian J. Leeper, Alan R. Battersby

Research output: Contribution to journalArticle

Abstract

Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B 12; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.

Original languageEnglish (US)
Pages (from-to)1061-1063
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number16
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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