Syntheses and configurational assignments of the diastereomers of the 4-nitrophenyl esters of thymidine 3′-(N-phenyl phosphoramidate) and thymidine 5′-(N-phenyl phosphoramidate)

John A. Gerlt; Shujaath Mehdi; Jeffrey A. Coderre; William O. Rogers

doi:10.1016/S0040-4039(00)93156-3

Syntheses and configurational assignments of the diastereomers of the 4-nitrophenyl esters of thymidine 3′-(N-phenyl phosphoramidate) and thymidine 5′-(N-phenyl phosphoramidate)

John A. Gerlt, Shujaath Mehdi, Jeffrey A. Coderre, William O. Rogers

Research output: Contribution to journal › Article › peer-review

Abstract

The separated diastereomers of 3′-(4-nitrophenyl N-phenyl phosphoramidate)-5′-monomethoxytrityl thymidine and 3′-monomethoxytrityl-5′-(4-nitrophenyl N-phenyl phosphoramidate) thymidine have been prepared and their absolute configurations at phosphorus have been determined.

Original language	English (US)
Pages (from-to)	2385-2388
Number of pages	4
Journal	Tetrahedron Letters
Volume	21
Issue number	25
DOIs	https://doi.org/10.1016/S0040-4039(00)93156-3
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Syntheses and configurational assignments of the diastereomers of the 4-nitrophenyl esters of thymidine 3′-(N-phenyl phosphoramidate) and thymidine 5′-(N-phenyl phosphoramidate). / Gerlt, John A.; Mehdi, Shujaath; Coderre, Jeffrey A. et al.
In: Tetrahedron Letters, Vol. 21, No. 25, 1980, p. 2385-2388.

Research output: Contribution to journal › Article › peer-review

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AU - Mehdi, Shujaath

AU - Coderre, Jeffrey A.

AU - Rogers, William O.

PY - 1980

Y1 - 1980

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AB - The separated diastereomers of 3′-(4-nitrophenyl N-phenyl phosphoramidate)-5′-monomethoxytrityl thymidine and 3′-monomethoxytrityl-5′-(4-nitrophenyl N-phenyl phosphoramidate) thymidine have been prepared and their absolute configurations at phosphorus have been determined.

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Syntheses and configurational assignments of the diastereomers of the 4-nitrophenyl esters of thymidine 3′-(N-phenyl phosphoramidate) and thymidine 5′-(N-phenyl phosphoramidate)

Abstract

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