Synergistic effects in gene delivery - A structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents

Simon P. Jones, Nathan P. Gabrielson, Daniel W. Pack, David K. Smith

Research output: Contribution to journalArticle

Abstract

Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability-we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.

Original languageEnglish (US)
Pages (from-to)4700-4702
Number of pages3
JournalChemical Communications
Issue number39
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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