Swine Genome Sequencing Consortium (SGSC): A strategic roadmap for sequencing the pig genome

Lawrence B. Schook, Jonathan E. Beever, Jane Rogers, Sean Humphray, Alan Archibald, Patrick Chardon, Denis Milan, Gary Rohrer, Kellye Eversole

Research output: Contribution to journalArticle

Abstract

The Swine Genome Sequencing Consortium (SGSC) was formed in September 2003 by academic, government and industry representatives to provide international coordination for sequencing the pig genome. The SGSC's mission is to advance biomedical research for animal production and health by the development of DNA-based tools and products resulting from the sequencing of the swine genome. During the past 2 years, the SGSC has met bi-annually to develop a strategic roadmap for creating the required scientific resources, to integrate existing physical maps, and to create a sequencing strategy that captured international participation and a broad funding base. During the past year, SGSC members have integrated their respective physical mapping data with the goal of creating a minimal tiling path (MTP) that will be used as the sequencing template. During the recent Plant and Animal Genome meeting (January 16, 2005 San Diego, CA), presentations demonstrated that a human-pig comparative map has been completed, BAC fingerprint contigs (FPC) for each of the autosomes and X chromosome have been constructed and that BAC end-sequencing has permitted, through BLAST analysis and RH-mapping, anchoring of the contigs. Thus, significant progress has been made towards the creation of a MTP. In addition, whole-genome (WG) shotgun libraries have been constructed and are currently being sequenced in various laboratories around the globe. Thus, a hybrid sequencing approach in which 3× coverage of BACs comprising the MTP and 3× of the WG-shotgun libraries will be used to develop a draft 6× coverage of the pig genome.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalComparative and Functional Genomics
Volume6
Issue number4
DOIs
StatePublished - Jun 2005

Keywords

  • Genomics
  • Physical maps
  • Pig genome
  • Porcine
  • Sequencing consortium
  • Whole-genome sequencing

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Biotechnology
  • Genetics(clinical)

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  • Cite this

    Schook, L. B., Beever, J. E., Rogers, J., Humphray, S., Archibald, A., Chardon, P., Milan, D., Rohrer, G., & Eversole, K. (2005). Swine Genome Sequencing Consortium (SGSC): A strategic roadmap for sequencing the pig genome. Comparative and Functional Genomics, 6(4), 251-255. https://doi.org/10.1002/cfg.479