Abstract

Hydrogels of 2-hydroxyethyl methacrylate (HEMA) cross-linked with N,N′-cystaminebis-(acrylamide) (CBA) were prepared inside microchannels using an in situ photopolymerization for the study of chemical-responsive microgels. By chemically reducing disulfide bonds with dithiothreitol (DTT), the cross-link density of the hydrogel network decreased, leading to an observable swelling of the hydrogel. To maximize swelling response, acrylic acid (AA) was copolymerized with HEMA and CBA to afford a pH/chemically-responsive hydrogel. The combination of a decrease in cross-link density and a driving force for swelling (deprotonation of AA) led to a fast swelling response. Hydrogel swelling switched between half- and first-order kinetics depending on hydrogel composition and de-cross-linking conditions. A direct relationship between the hydrogel swelling rate and the rate of cross-link cleavage was found. A linear dependence between the square of the swelling rate and DTT concentration suggests the possibility of using responsive hydrogels as a quantitative chemical sensor.

Original languageEnglish (US)
Pages (from-to)3960-3966
Number of pages7
JournalMacromolecules
Volume36
Issue number11
DOIs
StatePublished - Jun 3 2003

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Swelling kinetics of disulfide cross-linked microgels'. Together they form a unique fingerprint.

Cite this