Sustained release of bioactive compounds from polymer microcapsules for smart dental composites

M. Yourdkhani, N. Sottos, S. White

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Natural plant extracts have been shown as effective and attractive dental biomaterials with promising properties for restorative/reparative procedures. These bioactive extracts, however, may lose their stability when exposed to air, moisture, or light, if not well-protected. Here, we present a novel technique for sequestering bioactive extracts within polymer microcapsules for long-term stability and controlled release of active compounds as needed. We use a combination of water-oil-water (W/O/W) double emulsion and solvent evaporation techniques to encapsulate watersoluble bioactives within polymer microcapsules. Polylactide acid was used as the encapsulating polymer to provide sustained release of bioactive compounds from microcapsules. Manufactured microcapsules possess a polynuclear inner structure as a result of two-step double emulsion technique. We demonstrate the ability to control the size and core loading of microcapsules with varying the key microencapsulation parameters. 123.

Original languageEnglish (US)
Title of host publicationProceedings of the American Society for Composites - 31st Technical Conference, ASC 2016
EditorsBarry D. Davidson, Michael W. Czabaj, James G. Ratcliffe
PublisherDEStech Publications Inc.
ISBN (Electronic)9781605953168
StatePublished - Jan 1 2016
Event31st Annual Technical Conference of the American Society for Composites, ASC 2016 - Williamsburg, United States
Duration: Sep 19 2016Sep 21 2016

Publication series

NameProceedings of the American Society for Composites - 31st Technical Conference, ASC 2016

Other

Other31st Annual Technical Conference of the American Society for Composites, ASC 2016
CountryUnited States
CityWilliamsburg
Period9/19/169/21/16

ASJC Scopus subject areas

  • Ceramics and Composites

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    Yourdkhani, M., Sottos, N., & White, S. (2016). Sustained release of bioactive compounds from polymer microcapsules for smart dental composites. In B. D. Davidson, M. W. Czabaj, & J. G. Ratcliffe (Eds.), Proceedings of the American Society for Composites - 31st Technical Conference, ASC 2016 (Proceedings of the American Society for Composites - 31st Technical Conference, ASC 2016). DEStech Publications Inc..