Surfaces and Orientations: Much to FRET about?

Ivan Rasnik, Sean A. McKinney, Taekjip Ha

Research output: Contribution to journalArticlepeer-review


Single molecule FRET (fluorescence resonance energy transfer) is a powerful technique for detecting real-time conformational changes and molecular interactions during biological reactions. In this Account, we examine different techniques of extending observation times via immobilization and illustrate how useful biological information can be obtained from single molecule FRET time trajectories with or without absolute distance information.

Original languageEnglish (US)
Pages (from-to)542-548
Number of pages7
JournalAccounts of chemical research
Issue number7
StatePublished - Jul 2005

ASJC Scopus subject areas

  • General Chemistry


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