Surface immobilized DNAzyme for triggered response of monolayers

Daryl P. Wernette, Carla B. Swearingen, Yi Lu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

DNAzymes have been identified as interesting molecules for triggered response in nano-assemblies because activity can be extended beyond variables such as temperature, ionic strength or pH, to a target analyte. This work describes the use of a fluorophore labeled Pb2+-dependent DNAzyme for triggered monolayers on evaporated gold surfaces and within the pores of Aucoated polycarbonate track-etched membranes. The method for optimal formation of the active monolayer, as well as the response of the monolayer is described. Active control of binding and release of fluorophore from surfaces can be modified to include the same control over larger constituents such as nanoparticles.

Original languageEnglish (US)
Title of host publication2nd Conference on Foundations of Nanoscience
Subtitle of host publicationSelf-Assembled Architectures and Devices, FNANO 2005
Pages5-6
Number of pages2
StatePublished - 2005
Event2nd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2005 - Snowbird, UT, United States
Duration: Apr 24 2005Apr 28 2005

Other

Other2nd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2005
Country/TerritoryUnited States
CitySnowbird, UT
Period4/24/054/28/05

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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