Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology.

Yuling Wang, Joseph Irudayaraj

Research output: Contribution to journalReview article

Abstract

Single-molecule (SM) spectroscopy has been an exciting area of research offering significant promise and hope in the field of sensor development to detect targets at ultra-low levels down to SM resolution. To the experts and developers in the field of surface-enhanced Raman spectroscopy (SERS), this has often been a challenge and a significant opportunity for exploration. Needless to say, the opportunities and excitement of this multidisciplinary area impacts span the fields of physics, chemistry and engineering, along with a significant thrust in applications constituting areas in medicine, biology, environment and agriculture among others. In this review, we will attempt to provide a quick snapshot of the basics of SM-SERS, nanostructures and devices that can enable SM Raman measurement. We will conclude with a discussion on SERS implications in biomedical sciences.

Original languageEnglish (US)
Pages (from-to)20120026
Number of pages1
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume368
Issue number1611
StatePublished - Feb 5 2013
Externally publishedYes

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Raman spectroscopy
Raman Spectrum Analysis
Biological Sciences
Molecules
nanomaterials
Nanostructures
Physics
physics
Agriculture
sensors (equipment)
spectroscopy
medicine
engineering
chemistry
Medicine
agriculture
Equipment and Supplies
Spectroscopy
Research
Sensors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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abstract = "Single-molecule (SM) spectroscopy has been an exciting area of research offering significant promise and hope in the field of sensor development to detect targets at ultra-low levels down to SM resolution. To the experts and developers in the field of surface-enhanced Raman spectroscopy (SERS), this has often been a challenge and a significant opportunity for exploration. Needless to say, the opportunities and excitement of this multidisciplinary area impacts span the fields of physics, chemistry and engineering, along with a significant thrust in applications constituting areas in medicine, biology, environment and agriculture among others. In this review, we will attempt to provide a quick snapshot of the basics of SM-SERS, nanostructures and devices that can enable SM Raman measurement. We will conclude with a discussion on SERS implications in biomedical sciences.",
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