Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation

Lichen Yin; Ziyuan Song; Qiuhao Qu; Kyung Hoon Kim; Nan Zheng; Catherine Yao; Isthier Chaudhury; Haoyu Tang; Nathan P. Gabrielson; Fatih M. Uckun; Jianjun Cheng

doi:10.1002/anie.201209991

Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation

Lichen Yin
, Ziyuan Song
, Qiuhao Qu
, Kyung Hoon Kim
, Nan Zheng
, Catherine Yao
, Isthier Chaudhury
, Haoyu Tang
, Nathan P. Gabrielson
, Fatih M. Uckun
, Jianjun Cheng

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF-α production at an siRNA dose as low as 50μg kg^-1, and thus protects mice from lipopolysaccharide-induced hepatic injury.

Original language	English (US)
Pages (from-to)	5757-5761
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	22
DOIs	https://doi.org/10.1002/anie.201209991
State	Published - May 27 2013

Keywords

inflammation
nanoparticles
siRNA
supramolecular self-assembly
TNF-α

ASJC Scopus subject areas

General Chemistry
Catalysis

Online availability

10.1002/anie.201209991

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AU - Yin, Lichen

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AU - Qu, Qiuhao

AU - Kim, Kyung Hoon

AU - Zheng, Nan

AU - Yao, Catherine

AU - Chaudhury, Isthier

AU - Tang, Haoyu

AU - Gabrielson, Nathan P.

AU - Uckun, Fatih M.

AU - Cheng, Jianjun

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KW - nanoparticles

KW - siRNA

KW - supramolecular self-assembly

KW - TNF-α

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Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation

Abstract

Keywords

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