Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation

Lichen Yin, Ziyuan Song, Qiuhao Qu, Kyung Hoon Kim, Nan Zheng, Catherine Yao, Isthier Chaudhury, Haoyu Tang, Nathan P. Gabrielson, Fatih M. Uckun, Jianjun Cheng

Research output: Contribution to journalArticle

Abstract

A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF-α production at an siRNA dose as low as 50μg kg-1, and thus protects mice from lipopolysaccharide-induced hepatic injury.

Original languageEnglish (US)
Pages (from-to)5757-5761
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number22
DOIs
StatePublished - May 27 2013

Keywords

  • inflammation
  • nanoparticles
  • siRNA
  • supramolecular self-assembly
  • TNF-α

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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