Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation

Lichen Yin; Ziyuan Song; Qiuhao Qu; Kyung Hoon Kim; Nan Zheng; Catherine Yao; Isthier Chaudhury; Haoyu Tang; Nathan P. Gabrielson; Fatih M. Uckun; Jianjun Cheng

doi:10.1002/anie.201209991

Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation

Lichen Yin, Ziyuan Song, Qiuhao Qu, Kyung Hoon Kim, Nan Zheng, Catherine Yao, Isthier Chaudhury, Haoyu Tang, Nathan P. Gabrielson, Fatih M. Uckun, Jianjun Cheng

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF-α production at an siRNA dose as low as 50μg kg^-1, and thus protects mice from lipopolysaccharide-induced hepatic injury.

Original language	English (US)
Pages (from-to)	5757-5761
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	22
DOIs	https://doi.org/10.1002/anie.201209991
State	Published - May 27 2013

Keywords

inflammation
nanoparticles
siRNA
supramolecular self-assembly
TNF-α

ASJC Scopus subject areas

General Chemistry
Catalysis

Online availability

10.1002/anie.201209991

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AU - Yin, Lichen

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AU - Qu, Qiuhao

AU - Kim, Kyung Hoon

AU - Zheng, Nan

AU - Yao, Catherine

AU - Chaudhury, Isthier

AU - Tang, Haoyu

AU - Gabrielson, Nathan P.

AU - Uckun, Fatih M.

AU - Cheng, Jianjun

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Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation

Abstract

Keywords

ASJC Scopus subject areas

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