⁶⁴Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: Synthesis, radiolabeling, and biologic evaluation

Keyphrases

• Tumor Imaging 100%
• Folate Conjugate 100%
• Tumor Radiotherapy 100%
• Synthetic Evaluation 100%
• Biological Evaluation 100%
• Shell Cross-linked 100%
• Crosslinked Nanoparticles 100%
• Folate 42%
• Tumor 21%
• Folate Receptor 21%
• KB Cells 15%
• Fluorescein 10%
• Specific Interactions 10%
• Thiosemicarbazide 10%
• Solid Tumors 10%
• Biodistribution 10%
• After Injection 10%
• Autoradiography 10%
• Promising Drug 5%
• Percentage Yield 5%
• Vascularized 5%
• Tumor Cells 5%
• Liver 5%
• Cell Surface Receptor 5%
• Xenograft 5%
• Epifluorescence Microscopy 5%
• Overexpressing 5%
• Drug Delivery Agent 5%
• Radionuclides 5%
• Injected Dose 5%
• Imaging Agents 5%
• Optimum number 5%
• Passive Tumor Targeting 5%
• Active Tumor Targeting 5%
• Long-circulating Nanoparticles 5%
• Global Solution 5%
• Radiolabeled Compounds 5%
• Radiochemical Purity 5%
• Reticuloendothelial System Uptake 5%
• Necrotic Lesion 5%
• Efficiency Increase 5%
• Prolonged Blood Circulation 5%
• Amphiphilic Diblock Copolymer 5%
• Long Circulation 5%
• Solution State 5%
• Tumor Uptake 5%
• Tumor Accumulation 5%
• Athymic Mice 5%
• Functionalization Strategies 5%
• 64Cu Labeling 5%
• Tumor Distribution 5%
• Promising Applications 5%
• Targeted Agents 5%
• High Accumulation 5%
• Tetraazacyclotetradecane 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Nanoparticle 100%
• Neoplasm 100%
• Copper 64 100%
• Folic Acid 100%
• Folate Receptor 20%
• Fluorescein 10%
• Solid Malignant Neoplasm 10%
• Biodistribution 10%
• Autoradiography 10%
• Thiosemicarbazide 10%
• Copolymer 5%
• Micelle 5%
• Cell Surface Receptor 5%
• Cyclam 5%
• Nude Mouse 5%
• Radioisotope 5%
• Extravasation 5%