1H Magnetic resonance spectroscopy: A review of the current literature and its potential utility in veterinary oncology

Katherine Lynch, Robert O'Brien

Research output: Contribution to journalReview articlepeer-review

Abstract

Advanced imaging of veterinary cancer patients has evolved in recent years and modalities once limited to human medicine have now been described for diagnostic purposes in veterinary medicine (positron emission tomography/computed tomography, single-photon emission computed tomography, whole body magnetic resonance imaging). Magnetic resonance spectroscopy (MRS) is a non-invasive and non-ionizing technique that is well described in the human medical literature and is most frequently used to evaluate the metabolic activity of tissues with questionable malignant transformation. Differentiation of neoplastic tissue from surrounding normal tissue is dependent on variations in cellular metabolism. Positive identification of malignancy can be made when neoplastic alterations are occurring at the cellular level prior to gross anatomic changes. This improved, early detection of cancer occurrence (or recurrence) can improve patient survival and direct medical therapy. MRS techniques are largely underutilized in veterinary medicine, with current research predominantly limited to the brain (both evaluation of normal and diseased tissue). Given the clinical utility of MRS in humans, the technique may also be useful in the staging of cancer in veterinary medicine.

Original languageEnglish (US)
Pages (from-to)240-247
Number of pages8
JournalVeterinary Journal
Volume200
Issue number2
DOIs
StatePublished - May 2014

Keywords

  • Choline
  • Imaging
  • Magnetic resonance spectroscopy
  • Oncology
  • Veterinary

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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