13C NMR Signal Enhancement Using Parahydrogen-Induced Polarization Mediated by a Cobalt Hydrogenation Catalyst

Kenan Tokmic, Rianna B. Greer, Lingyang Zhu, Alison Renee Weitzel

Research output: Contribution to journalArticle

Abstract

The use of a cobalt-based catalyst for the generation of hyperpolarized 13C NMR resonances by parahydrogenation of ethyl acrylate is presented herein. Comparisons of the carboxylate 13C NMR signal enhancement factor of ethyl propionate between using (MesCCC)Co-py and a commonly utilized cationic diphosphine rhodium complex demonstrates that the cobalt system is a viable PHIP catalyst alternative. Furthermore, the operative hydrogenation mechanism of the cobalt system was examined by using 1H, 13C, and parahydrogen-induced polarization NMR spectroscopies to elucidate reaction intermediates affiliated with the observed 1H and 13C NMR signal enhancements in ethyl propionate.

Original languageEnglish (US)
Pages (from-to)14844-14850
Number of pages7
JournalJournal of the American Chemical Society
Volume140
Issue number44
DOIs
StatePublished - Nov 7 2018

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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