Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion

Joell J. Gills, Elizabeth H. Jeffery, Nathan V. Matusheski, Richard C. Moon, Daniel D. Lantvit, John M. Pezzuto

Research output: Contribution to journalArticle

Abstract

Sulforaphane (SF), a natural product from broccoli, is known to enhance detoxification of carcinogens and block initiation of chemically-induced carcinogenesis in animal models. Cell culture and xenograft studies suggest additional roles for SF, inhibiting growth of tumors, arresting the cell cycle and enhancing apoptosis. As currently reported, topical SF (1, 5 or 10 μmol/mouse) significantly inhibited 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse skin tumorigenesis, using either an anti-promotion protocol (SF from 1 week after carcinogen until the end of the study) or a combined anti-initiation, anti-promotion protocol (SF 7 days prior to carcinogen until the end of the study). Surprisingly, no significant effect was observed in an anti-initiation protocol (SF from 7 days prior to 7 days after carcinogen). Separately, SF inhibited TPA-induced ornithine decarboxylase activity in mouse skin, an obligate step in TPA-induced promotion of carcinogenesis. These data link this molecular mechanism to SF-dependent inhibition of the promotion of tumorigenesis.

Original languageEnglish (US)
Pages (from-to)72-79
Number of pages8
JournalCancer Letters
Volume236
Issue number1
DOIs
StatePublished - May 8 2006

Keywords

  • 12-O-Tetradecanoylphorbol 13-acetate.
  • 7,12-Dimethylbenz(a)anthracene
  • Isothiocyanate
  • Ornithine decarboxylase
  • Sulforaphane

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Gills, J. J., Jeffery, E. H., Matusheski, N. V., Moon, R. C., Lantvit, D. D., & Pezzuto, J. M. (2006). Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion. Cancer Letters, 236(1), 72-79. https://doi.org/10.1016/j.canlet.2005.05.007