Substituted pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones for cancer treatment

Justin Kim (Inventor), Paul J Hergenrother (Inventor), Mohammad Movassaghi (Inventor), Nicolas C Boyer (Inventor), Karen C Morrison (Inventor)

Research output: Patent


The synthesis of various pyrazino[1′,2′:1,5]pyrrolo[2,3-B]-indole-1,4-dione analogs has been successfully implemented in the present application. From these efforts, compounds having the structure of Formula I-a or Formula I-b: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, are provided herein. These biologically active derivatives have been used to effectively treat various diseases including cancer.
Original languageEnglish (US)
U.S. patent number10918735
StatePublished - Feb 26 2021


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