Substituted 1,3,5-triazaadamantanes: Biocompatible and degradable building blocks

Amy M. Balija, Richie E. Kohman, Steven C. Zimmerman

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented) Basic groups from acid hydrolysis: 1,3,5-Triazaadamantanes (TAAs) are shown to degrade in acidic conditions to produce basic byproducts (see scheme). The rate of hydrolysis can be tuned by changing the substituents present on the aromatic rings. TAA-containing dendrimers can be synthesized readily as a result of the branched architecture ofthe TAA building blocks.

Original languageEnglish (US)
Pages (from-to)8072-8074
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number42
StatePublished - Oct 6 2008


  • Degradation
  • Dendrimers
  • Host-guest systems
  • Hydrolysis
  • Macromolecules

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis


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