Substituted 1,3,5-triazaadamantanes: Biocompatible and degradable building blocks

Amy M. Balija; Richie E. Kohman; Steven C. Zimmerman

doi:10.1002/anie.200802222

Substituted 1,3,5-triazaadamantanes: Biocompatible and degradable building blocks

Amy M. Balija, Richie E. Kohman, Steven C. Zimmerman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) Basic groups from acid hydrolysis: 1,3,5-Triazaadamantanes (TAAs) are shown to degrade in acidic conditions to produce basic byproducts (see scheme). The rate of hydrolysis can be tuned by changing the substituents present on the aromatic rings. TAA-containing dendrimers can be synthesized readily as a result of the branched architecture ofthe TAA building blocks.

Original language	English (US)
Pages (from-to)	8072-8074
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	42
DOIs	https://doi.org/10.1002/anie.200802222
State	Published - Oct 6 2008

Keywords

Degradation
Dendrimers
Host-guest systems
Hydrolysis
Macromolecules

ASJC Scopus subject areas

General Chemistry
Catalysis

Online availability

10.1002/anie.200802222

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AU - Zimmerman, Steven C.

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AB - (Chemical Equation Presented) Basic groups from acid hydrolysis: 1,3,5-Triazaadamantanes (TAAs) are shown to degrade in acidic conditions to produce basic byproducts (see scheme). The rate of hydrolysis can be tuned by changing the substituents present on the aromatic rings. TAA-containing dendrimers can be synthesized readily as a result of the branched architecture ofthe TAA building blocks.

KW - Degradation

KW - Dendrimers

KW - Host-guest systems

KW - Hydrolysis

KW - Macromolecules

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Substituted 1,3,5-triazaadamantanes: Biocompatible and degradable building blocks

Abstract

Keywords

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