Substituents at the C13 Position of Retinal and Their Influence on the Function of Bacteriorhodopsin

Paul Tavan, Klaus Schulten, Wolfgang Gärtner, Dieter Oesterhelt

Research output: Contribution to journalArticlepeer-review


Retinal analogues in which the 13-methyl group is replaced by H, C2H5, CF3, and OCH3 residues are studied by means of quantumchemical modified neglect of diatomic overlap-correlated version (MNDOC) calculations. The analogues are suitable to test the stereochemical mechanism of proton pumping in bacteriorhodopsin. The results explain the proton-pumping activities of bacterio-opsin reconstituted with these analogues and elucidate the decisive role of retinal's ground-state intramolecular properties in the pump cycle of bacteriorhodopsin.

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalBiophysical journal
Issue number3
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics


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