Sublancin is not a lantibiotic but an S-linked glycopeptide

Trent J. Oman, John M. Boettcher, Huan Wang, Xenia N. Okalibe, Wilfred A. Van Der Donk

Research output: Contribution to journalArticlepeer-review


Sublancin is shown to be an S-linked glycopeptide containing a glucose attached to a cysteine residue, establishing a new post-translational modification. The activity of the S-glycosyl transferase was reconstituted in vitro, and the enzyme is shown to have relaxed substrate specificity, allowing the preparation of analogs of sublancin. Glycosylation is essential for its antimicrobial activity.

Original languageEnglish (US)
Pages (from-to)78-80
Number of pages3
JournalNature chemical biology
Issue number2
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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