Study blinding and correlations between perceived group assignment and outcome in a cocaine pharmacotherapy trial

Catharine E. Fairbairn; William D. Dundon; Hu Xie; Jennifer G. Plebani; Kyle M. Kampman; Kevin G. Lynch

doi:10.1080/10550490802266078

Study blinding and correlations between perceived group assignment and outcome in a cocaine pharmacotherapy trial

Catharine E. Fairbairn, William D. Dundon, Hu Xie, Jennifer G. Plebani, Kyle M. Kampman, Kevin G. Lynch

Research output: Contribution to journal › Article › peer-review

Abstract

While much research has suggested that the integrity of the blind is compromised in psychotropic drug trials, little research has been conducted on blinding in substance abuse trials. The current study examines the integrity of the blind in an outpatient pharmacotherapy trial investigating the effectiveness of amantadine and propranolol in treating cocaine addiction. Results suggest that neither nurses (N = 174, kappa = 0.08, p = 0.22) nor participants (N = 163, kappa = 0.09, p = 0.26) could accurately predict treatment assignment. Furthermore, nurses' perceptions of treatment assignment were significantly related to trial completion, medication compliance, and cocaine use - results that may have training implications for medical personnel.

Original language	English (US)
Pages (from-to)	387-391
Number of pages	5
Journal	American Journal on Addictions
Volume	17
Issue number	5
DOIs	https://doi.org/10.1080/10550490802266078
State	Published - Sep 2008
Externally published	Yes

ASJC Scopus subject areas

Medicine (miscellaneous)
Clinical Psychology
Psychiatry and Mental health

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10.1080/10550490802266078

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AU - Kampman, Kyle M.

AU - Lynch, Kevin G.

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Study blinding and correlations between perceived group assignment and outcome in a cocaine pharmacotherapy trial

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