Abstract
This paper presents studies on the genotoxicity of two aminophenazines: 2,3-diaminophenazine (DAP) and 2-amino-3-hydroxyphenazine (AHP). The genotoxic activities of these compounds were evaluated with human lymphocytes using the alkaline single cell gel electrophoresis (SCGE) assay and two cytogenetic assays (chromosome aberrations (CA) and sister chromatid exchange (SCE) analysis). Results show that these chemicals elicited an increase in DNA and chromosomal damage under the studied ranges of concentration. Concentration-response curves were similar and there was a positive correlation between the damage observed at the DNA and chromosomal levels. DAP was more genotoxic than AHP and this agreed with the genotoxic potencies reported in bacterial systems. Copyright (C) 1999 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 57-65 |
Number of pages | 9 |
Journal | Mutation Research - Genetic Toxicology and Environmental Mutagenesis |
Volume | 446 |
Issue number | 1 |
DOIs | |
State | Published - Oct 29 1999 |
Externally published | Yes |
Keywords
- Aminophenazines
- Human lymphocytes
- Single cell gel electrophoresis
ASJC Scopus subject areas
- Genetics
- Health, Toxicology and Mutagenesis