Studies on the genotoxic effects of aminophenazines using two cellular models and three different methods

A. Cebulska-Wasilewska, D. Nowak, W. Niedzwiedz, Elizabeth D. Wagner, Michael J. Plewa

Research output: Contribution to journalArticlepeer-review

Abstract

This paper presents studies on the genotoxicity of two aminophenazines: 2,3-diaminophenazine (DAP) and 2-amino-3-hydroxyphenazine (AHP). The genotoxic activities of these compounds were evaluated with human lymphocytes using the alkaline single cell gel electrophoresis (SCGE) assay and two cytogenetic assays (chromosome aberrations (CA) and sister chromatid exchange (SCE) analysis). Results show that these chemicals elicited an increase in DNA and chromosomal damage under the studied ranges of concentration. Concentration-response curves were similar and there was a positive correlation between the damage observed at the DNA and chromosomal levels. DAP was more genotoxic than AHP and this agreed with the genotoxic potencies reported in bacterial systems. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)57-65
Number of pages9
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume446
Issue number1
DOIs
StatePublished - Oct 29 1999
Externally publishedYes

Keywords

  • Aminophenazines
  • Human lymphocytes
  • Single cell gel electrophoresis

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Studies on the genotoxic effects of aminophenazines using two cellular models and three different methods'. Together they form a unique fingerprint.

Cite this