TY - JOUR
T1 - Studies on the genotoxic effects of aminophenazines using two cellular models and three different methods
AU - Cebulska-Wasilewska, A.
AU - Nowak, D.
AU - Niedzwiedz, W.
AU - Wagner, Elizabeth D.
AU - Plewa, Michael J.
N1 - Funding Information:
Research was partially supported by contract ERBIC 15CT960300 of the Commission of the European Communities. We would like to thank Prof. K. Chruścielska from the Institute of Organic Industry, Warsaw, for supplying aminophenazines.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/10/29
Y1 - 1999/10/29
N2 - This paper presents studies on the genotoxicity of two aminophenazines: 2,3-diaminophenazine (DAP) and 2-amino-3-hydroxyphenazine (AHP). The genotoxic activities of these compounds were evaluated with human lymphocytes using the alkaline single cell gel electrophoresis (SCGE) assay and two cytogenetic assays (chromosome aberrations (CA) and sister chromatid exchange (SCE) analysis). Results show that these chemicals elicited an increase in DNA and chromosomal damage under the studied ranges of concentration. Concentration-response curves were similar and there was a positive correlation between the damage observed at the DNA and chromosomal levels. DAP was more genotoxic than AHP and this agreed with the genotoxic potencies reported in bacterial systems. Copyright (C) 1999 Elsevier Science B.V.
AB - This paper presents studies on the genotoxicity of two aminophenazines: 2,3-diaminophenazine (DAP) and 2-amino-3-hydroxyphenazine (AHP). The genotoxic activities of these compounds were evaluated with human lymphocytes using the alkaline single cell gel electrophoresis (SCGE) assay and two cytogenetic assays (chromosome aberrations (CA) and sister chromatid exchange (SCE) analysis). Results show that these chemicals elicited an increase in DNA and chromosomal damage under the studied ranges of concentration. Concentration-response curves were similar and there was a positive correlation between the damage observed at the DNA and chromosomal levels. DAP was more genotoxic than AHP and this agreed with the genotoxic potencies reported in bacterial systems. Copyright (C) 1999 Elsevier Science B.V.
KW - Aminophenazines
KW - Human lymphocytes
KW - Single cell gel electrophoresis
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U2 - 10.1016/S1383-5718(99)00149-7
DO - 10.1016/S1383-5718(99)00149-7
M3 - Article
C2 - 10613186
AN - SCOPUS:0032729355
SN - 1383-5718
VL - 446
SP - 57
EP - 65
JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
IS - 1
ER -