Studies of the dynamics of biological macromolecules using Au nanoparticle-DNA artificial molecules

Qian Chen, Jessica M. Smith, Haider I. Rasool, Alex Zettl, A. Paul Alivisatos

Research output: Contribution to journalArticlepeer-review

Abstract

The recent development of graphene liquid cells, a nanoscale version of liquid bubble wrap, is a breakthrough for in situ liquid phase electron microscopy (EM). Using ultrathin graphene sheets as the liquid sample container, graphene liquid cells have allowed the unprecedented atomic resolution observation of solution phase growth and dynamics of nanocrystals. Here we explore the potential of this technique to probe nanoscale structure and dynamics of biomolecules in situ, using artificial Au nanoparticle-DNA artificial molecules as model systems. The interactions of electrons with both the artificial molecules and the liquid environment have been demonstrated and discussed, revealing both the opportunities and challenges of using graphene liquid cell EM as a new method of bio-imaging.

Original languageEnglish (US)
Pages (from-to)203-214
Number of pages12
JournalFaraday Discussions
Volume175
DOIs
StatePublished - Dec 8 2014
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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