Structures of fluoro, amino, and thiol inhibitors bound to the [Fe 4S4] protein IspH

Ingrid Span, Ke Wang, Weixue Wang, Johann Jauch, Wolfgang Eisenreich, Adelbert Bacher, Eric Oldfield, Michael Groll

Research output: Contribution to journalArticlepeer-review

Abstract

The iron-sulfur protein IspH catalyzes a key step in isoprenoid biosynthesis in bacteria and malaria parasites. Crystal structures of IspH complexed with three substrate analogues reveal their mode of binding and suggest new routes to inhibitor design.

Original languageEnglish (US)
Pages (from-to)2118-2121
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number7
DOIs
StatePublished - Feb 11 2013

Keywords

  • IspH
  • LytB
  • bioinorganic chemistry
  • metalloenzymes
  • terpenoids

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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