Structure, organization, and somatic rearrangement of T cell gamma genes

Adrian C. Hayday, Haruo Saito, Stephen D. Gillies, David M Kranz, Gary Tanigawa, Herman N. Eisen, Susumu Tonegawa

Research output: Contribution to journalArticle

Abstract

We present the initial characterization of a novel family of genes that rearrange in T cells, but do not encode either of the defined (α/β) subunits of the clonespecific heterodimer of the T cell receptor. The family comprises at least three variable (V) gene segments, three constant (C) gene segments, and three junction (J) gene segments. In a cloned cytolytic T lymphocyte, 2C, one of each of these fragments has productively rearranged to yield an expressed VJC transcription unit, which shows no evidence for somatic mutation. Short sequences similar to those implicated in immunoglobulin gene and T cell receptor β chain gene rearrangement flank the V and J segments of this family. The linkage of two of the three V gene segments has been determined: the segments lie approximately 2.5 kb apart, and are arranged head-to-head. The inverted arrangement may cast light upon the mechanisms utilized by lymphocytes for gene rearrangement.

Original languageEnglish (US)
Pages (from-to)259-269
Number of pages11
JournalCell
Volume40
Issue number2
DOIs
StatePublished - Feb 1985
Externally publishedYes

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T-Lymphocyte Gene Rearrangement
T-cells
Genes
Gene Rearrangement
T-Lymphocytes
T-Cell Receptor Genes
T-Cell Antigen Receptor
Immunoglobulin Genes
Lymphocytes
Transcription
Mutation
Immunoglobulins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hayday, A. C., Saito, H., Gillies, S. D., Kranz, D. M., Tanigawa, G., Eisen, H. N., & Tonegawa, S. (1985). Structure, organization, and somatic rearrangement of T cell gamma genes. Cell, 40(2), 259-269. https://doi.org/10.1016/0092-8674(85)90140-0

Structure, organization, and somatic rearrangement of T cell gamma genes. / Hayday, Adrian C.; Saito, Haruo; Gillies, Stephen D.; Kranz, David M; Tanigawa, Gary; Eisen, Herman N.; Tonegawa, Susumu.

In: Cell, Vol. 40, No. 2, 02.1985, p. 259-269.

Research output: Contribution to journalArticle

Hayday, AC, Saito, H, Gillies, SD, Kranz, DM, Tanigawa, G, Eisen, HN & Tonegawa, S 1985, 'Structure, organization, and somatic rearrangement of T cell gamma genes', Cell, vol. 40, no. 2, pp. 259-269. https://doi.org/10.1016/0092-8674(85)90140-0
Hayday AC, Saito H, Gillies SD, Kranz DM, Tanigawa G, Eisen HN et al. Structure, organization, and somatic rearrangement of T cell gamma genes. Cell. 1985 Feb;40(2):259-269. https://doi.org/10.1016/0092-8674(85)90140-0
Hayday, Adrian C. ; Saito, Haruo ; Gillies, Stephen D. ; Kranz, David M ; Tanigawa, Gary ; Eisen, Herman N. ; Tonegawa, Susumu. / Structure, organization, and somatic rearrangement of T cell gamma genes. In: Cell. 1985 ; Vol. 40, No. 2. pp. 259-269.
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