Structure, organization, and somatic rearrangement of T cell gamma genes

Adrian C. Hayday, Haruo Saito, Stephen D. Gillies, David M. Kranz, Gary Tanigawa, Herman N. Eisen, Susumu Tonegawa

Research output: Contribution to journalArticlepeer-review


We present the initial characterization of a novel family of genes that rearrange in T cells, but do not encode either of the defined (α/β) subunits of the clonespecific heterodimer of the T cell receptor. The family comprises at least three variable (V) gene segments, three constant (C) gene segments, and three junction (J) gene segments. In a cloned cytolytic T lymphocyte, 2C, one of each of these fragments has productively rearranged to yield an expressed VJC transcription unit, which shows no evidence for somatic mutation. Short sequences similar to those implicated in immunoglobulin gene and T cell receptor β chain gene rearrangement flank the V and J segments of this family. The linkage of two of the three V gene segments has been determined: the segments lie approximately 2.5 kb apart, and are arranged head-to-head. The inverted arrangement may cast light upon the mechanisms utilized by lymphocytes for gene rearrangement.

Original languageEnglish (US)
Pages (from-to)259-269
Number of pages11
Issue number2
StatePublished - Feb 1985
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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