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Structure of the human dopamine transporter and mechanisms of inhibition
Dushyant Kumar Srivastava
, Vikas Navratna
, Dilip K. Tosh
, Audrey Chinn
, Md Fulbabu Sk
,
Emad Tajkhorshid
, Kenneth A. Jacobson
, Eric Gouaux
Biochemistry
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peer-review
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Keyphrases
Zn2+
100%
Inhibition Mechanism
100%
Human Dopamine Transporter
100%
Extracellular Loop
75%
Transmembrane Helix
50%
Small Molecules
25%
High-resolution
25%
Brain Function
25%
Open Conformation
25%
Therapeutic Agents
25%
Competitive Inhibitor
25%
Arousal
25%
Tripartite Complex
25%
Vestibule
25%
Illicit Drugs
25%
Allosteric Site
25%
Transport Activity
25%
Central Site
25%
Brain Physiology
25%
Structural Context
25%
Non-competitive Inhibitor
25%
Outward-facing Conformation
25%
Neurotransmitter Dopamine
25%
4-fluorophenyl
25%
Membrane Stabilizing
25%
Cocaine Analog
25%
Biochemistry, Genetics and Molecular Biology
Dopamine Transporter
100%
Conformation
66%
Competitive Inhibition
66%
Neurotransmitter
33%
Small Molecule
33%
K-Complex
33%
Allosteric Site
33%