Abstract
Pba1-Pba2 facilitates proteasome α-ring assembly. Results: Pba1-Pba2 binds mature proteasomes using C-terminal motifs and sequesters α-subunitNtermini. It does not activate and is not degraded by isolated 20S proteasomes. Conclusion: Pba1-Pba2 is important for proteasome-dependent maintenance of mitochondrial function. The structure is consistent with multiple roles in proteasome assembly. Significance: Models of proteasome assembly and Pba1-Pba2 proteasome function are advanced.
Original language | English (US) |
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Pages (from-to) | 37371-37382 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 287 |
Issue number | 44 |
DOIs | |
State | Published - Oct 26 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology