Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains

Hai Bing Zhou, Shubin Sheng, Dennis R. Compton, Younchang Kim, Andrzej Joachimiak, Sanjay Sharma, Kathryn E. Carlson, Benita S. Katzenellenbogen, Kendall W. Nettles, Geoffrey L. Greene, John A. Katzenellenbogen

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