Abstract
We report here the enzymatic biosynthesis of FR-900098 analogues and establish an in vivo platform for the biosynthesis of an N-propionyl derivative FR-900098P. FR-900098P is found to be a significantly more potent inhibitor of Plasmodium falciparum 1-deoxy-d-xylulose 5-phosphate reductoisomerase (PfDxr) than the parent compound, and thus a more promising antimalarial drug candidate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2526-2528 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 51 |
| Issue number | 13 |
| DOIs | |
| State | Published - Feb 14 2015 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- General Chemistry
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Catalysis