Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles

Benita S. Katzenellenbogen; Jun Sun; William R. Harrington; Dennis M. Kraichely; Deshanie Ganessunker; John A. Katzenellenbogen

doi:10.1111/j.1749-6632.2001.tb03998.x

Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles

Benita S. Katzenellenbogen, Jun Sun, William R. Harrington, Dennis M. Kraichely, Deshanie Ganessunker, John A. Katzenellenbogen

Molecular and Integrative Physiology

Research output: Contribution to journal › Article › peer-review

Abstract

This article summarizes recent research on the development of estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) subtype-selective ligands based on our understanding of structure-activity relationships in these two estrogen receptors and differences in their ligand binding domains and activation function domains. The use of these ligands should enable greater understanding of the unique biologies mediated by ERα versus ERβ and may, as well, provide selective estrogen receptor modulators having unique biological and pharmacological profiles optimal for prevention and treatment of breast cancer, for menopausal hormone replacement, for prevention of osteoporosis, and for potential cardiovascular benefit.

Original language	English (US)
Pages (from-to)	6-15
Number of pages	10
Journal	Annals of the New York Academy of Sciences
Volume	949
DOIs	https://doi.org/10.1111/j.1749-6632.2001.tb03998.x
State	Published - 2001

Keywords

Coactivators
ERα
ERβ
SERMs

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

Online availability

10.1111/j.1749-6632.2001.tb03998.x

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Katzenellenbogen, B. S., Sun, J., Harrington, W. R., Kraichely, D. M., Ganessunker, D., & Katzenellenbogen, J. A. (2001). Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles. Annals of the New York Academy of Sciences, 949, 6-15. https://doi.org/10.1111/j.1749-6632.2001.tb03998.x

Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles. / Katzenellenbogen, Benita S.; Sun, Jun; Harrington, William R. et al.
In: Annals of the New York Academy of Sciences, Vol. 949, 2001, p. 6-15.

Research output: Contribution to journal › Article › peer-review

Katzenellenbogen, BS, Sun, J, Harrington, WR, Kraichely, DM, Ganessunker, D & Katzenellenbogen, JA 2001, 'Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles', Annals of the New York Academy of Sciences, vol. 949, pp. 6-15. https://doi.org/10.1111/j.1749-6632.2001.tb03998.x

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Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles

Abstract

Keywords

ASJC Scopus subject areas

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